Symptoms of Sdb and Risk of Cancer: a Prospective Cohort Study

1429 SDB and Cancer Risk—Christensen et al INTRODUCTION Sleep disordered breathing (SDB) is a prevalent condition in modern society, estimated to affect 24% of men and 9% of women. SDB refers to a range of sleep disorders characterized by breathing cessations during sleep, often accompanied by snoring. Most often the interruption of ventilation is caused by partial or complete closure of the upper airway, also known as obstructive sleep apnea. Such interruptions will cause decreased blood oxygen saturation and sleep fragmentation, which in many instances will lead to daytime sleepiness. SDB has been associated with reduced quality of life and a higher risk of cardiometabolic disorders and all-cause mortality in a number of studies, but studies assessing the relationship between SDB and cancer are few. Experimental and observational studies have shown that sleep impairment is associated with several factors related to cancer initiation and promotion such as inflammation, oxidative stress, hormonal levels, and alterations of the SYMPTOMS OF SDB AND RISK OF CANCER: A PROSPECTIVE COHORT STUDY